Related Experiment Video
Updated: Oct 26, 2025
11:30
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
24.5K
Colloidal and vesicular delivery system for herbal bioactive constituents
Ravindra Pandey1, Monika Bhairam2, Shiv Shankar Shukla2
1Columbia Institute of Pharmacy Raipur, Raipur, Chhattisgarh, India. ravindraiop@gmail.com.
Summary
Novel nano-delivery systems enhance herbal medicine effectiveness by overcoming challenges like poor solubility and bioavailability. These advanced strategies improve drug properties and therapeutic outcomes for herbal constituents.
Area of Science:
- Pharmacology
- Drug Delivery
- Natural Products
Background:
- Herbal medicines offer therapeutic benefits with fewer side effects but face challenges like poor solubility, permeation, and stability.
- These limitations hinder the full potential of herbal constituents and plant actives in treating various ailments.
Purpose of the Study:
- To review and analyze novel techniques for improving the delivery of herbal constituents.
- To explore the effectiveness of nano-delivery systems in overcoming challenges associated with herbal extracts.
Main Methods:
- Systematic literature search of Science Direct, PubMed, and Google Scholar using relevant keywords.
- Critical analysis and synthesis of findings on nano-strategies for herbal drug delivery.
Main Results:
- Nano-strategies, including nanoparticles, liposomes, and nanoemulsions, significantly improve physicochemical properties, pharmacokinetics, and pharmacodynamics of herbal drugs.
- Nanoformulations enhance solubility, bioavailability, stability, and reduce toxicity of phytoconstituents.
- These approaches offer sustained delivery and protection from degradation.
Conclusions:
- Nano-sized novel drug delivery systems hold significant potential for enhancing the pharmacological action of herbal medicines.
- These advanced systems can effectively address and overcome the inherent issues associated with herbal constituents and bioactives.
- Further research into nano-strategies for phytochemical delivery promises improved therapeutic applications.
Related Concept Videos
01:16Drug Delivery: Overview
497
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
497
01:27Bioavailability Enhancement: Drug Permeability Enhancement
36
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
36
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
31
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
31
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
30
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
30
01:18Drug Delivery: Enteral Route
948
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
948
01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
1.1K
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
1.1K