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Updated: Oct 26, 2025
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
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The RNA regulatory programs that govern lymphocyte development and function.
Manuel D Diaz-Muñoz1, Ines C Osma-Garcia1
1Toulouse Institute for Infectious and Inflammatory Diseases, Inserm UMR1291, CNRS UMR5051, University Paul Sabatier, Toulouse, France.
Wiley Interdisciplinary Reviews. RNA
|July 30, 2021
Summary
RNA binding proteins (RBPs) dynamically regulate lymphocyte gene expression for immunity. These RBPs control RNA fate, shaping immune cell function and potentially revealing a hidden immune cell epitranscriptome.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Lymphocytes need dynamic transcriptome changes for activation and pathogen defense.
- RNA binding proteins (RBPs) control messenger RNA (mRNA) synthesis and translation.
- RBPs influence immune cell development and immunity through RNA regulation.
Purpose of the Study:
- To review how RBP-dependent RNA regulation shapes the immune system.
- To discuss the concept of a hidden immune cell epitranscriptome.
Main Methods:
- Review of current knowledge on RBPs and RNA regulation in immunity.
- Discussion of recent methodologies for global protein:RNA interaction characterization.
Main Results:
- RBPs quantitatively and qualitatively control mRNA fate (editing, location, stability, translation).
- RBPs form complex regulatory networks coordinating RNA molecules.
- RNA can scaffold proteins, modulating their function.
Conclusions:
- RBP-mediated RNA regulation is crucial for immune system function.
- The immune cell epitranscriptome represents a significant area for future research.
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