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A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
Published on: July 31, 2017
Validation of Autism Diagnosis and Clinical Data in the SPARK Cohort
Eric Fombonne1,2, Leigh Coppola3, Sarah Mastel3
1Department of Psychiatry, Oregon Health & Science University, Mail code: GH254, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA. fombonne@ohsu.edu.
Abstract:
The SPARK cohort was established to facilitate recruitment in studies of large numbers of participants with autism spectrum disorder (ASD). Online registration requires participants to have received a lifetime professional diagnosis by health or school providers although diagnoses are not independently verified. This study was set to examine the validity of self- and caregiver-reported autism diagnoses. Electronic medical records (EMR) of 254 SPARK participants (77.6% male, age 10.7 years) were abstracted. Using two different methods, confirmation of ASD diagnosis in EMRs was obtained in 98.8% of cases. Core clinical features recorded in EMRs were typical of autism samples and showed very good agreement with SPARK cohort data, providing further evidence of the validity of clinical information in the SPARK database.
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