[Repeated spontaneous abortion syndrome. Current status of the topic]

In recurrent spontaneous miscarriages, the etiological work-up must seek for an immunological cause when the gynecological work-up, hysterography and parent's caryotypes are normal. In the first part of the article, the problem of the association recurrent miscarriages-anti-prothrombinase antibodies is presented. A review of the literature shows that this antibody would be present in approximately 10 per cent of the cases of recurrent miscarriages. They imply a specific treatment during pregnancy. The immunological work-up may also indicates an abnormal maternal tolerance of the fetus which presents currently a controverted immunological problem. Its treatment requires a stimulation of maternal immunotolerance, of which the methods and results in terms of our experience and the literature are discussed in the second part of the article.