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Updated: Oct 26, 2025

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Purinergic signalling in the urinary bladder - When function becomes dysfunction.

Christopher H Fry1, Karen D McCloskey2

  • 1School of Physiology, Pharmacology & Neuroscience, Faculty of Health Sciences, University of Bristol, Bristol, UK.

Autonomic Neuroscience : Basic & Clinical
|July 30, 2021
PubMed
Summary
This summary is machine-generated.

Adenosine triphosphate (ATP) and purines play key roles in urinary tract function, influencing bladder pain, sensations, and motility. This review details their impact on normal physiology and bladder dysfunction.

Keywords:
ATPPhysiologySmooth muscleUrinary bladderUrothelium

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Area of Science:

  • Urology
  • Physiology
  • Pharmacology

Background:

  • Decades of research, inspired by Professor Geoffrey Burnstock, have elucidated the role of purines in the urinary tract.
  • Adenosine triphosphate (ATP) and related purines are crucial signaling molecules in the urinary system.

Purpose of the Study:

  • To summarize current knowledge on purines and purinergic signaling in urinary tract function.
  • To review the historical development of understanding purinergic mechanisms in the urinary tract.
  • To discuss the role of purinergic signaling in both normal physiology and bladder dysfunction.

Main Methods:

  • Review of historical and current scientific literature.
  • Consolidation of knowledge on purinergic signaling pathways.
  • Examination of developing methodologies and pharmacological tools.

Main Results:

  • Purinergic mechanisms are fundamental to bladder pain, sensations of filling, and urinary tract motility.
  • Detrusor smooth muscle contraction is regulated by purinergic signaling.
  • Purinergic signaling components (receptors, signal transduction, effector molecules) are implicated in bladder dysfunction.

Conclusions:

  • Purinergic signaling is integral to normal urinary tract function, including development and aging.
  • Dysregulation of purinergic mechanisms significantly contributes to bladder dysfunction.
  • Understanding these pathways is vital for addressing urological conditions.