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Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Related Experiment Video

Updated: Oct 26, 2025

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
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A longitudinal quality improvement program to optimize experiential education's ability to develop trusted

Wesley Nuffer1, Jay Bolan2, Laura M Borgelt3

  • 1Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, 12850 E Montview Blvd., Aurora, CO 80045, United States.

Currents in Pharmacy Teaching & Learning
|July 31, 2021
PubMed
Summary

Student pharmacists gain independence through a 20-year curriculum development process. This approach ensures graduates are prepared for autonomous and team-based pharmacy practice.

Keywords:
Entrustable professional activitiesExperiential educationIndependent practitionerInterprofessionalStudent pharmacist

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Area of Science:

  • Pharmacy Education
  • Experiential Learning
  • Curriculum Development

Background:

  • The evolving role of pharmacists necessitates independent practice skills for student pharmacists.
  • Students must be prepared for both autonomous work and interprofessional collaboration.

Purpose of the Study:

  • To describe a 20-year process of developing student independence in pharmacy experiential programs.
  • To demonstrate how increasing rigor and responsibility prepare students for modern pharmacy practice.

Main Methods:

  • Implemented a 20-year curricular modification process at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences.
  • Gradually increased student challenges and responsibilities through experiential practice settings.
  • Utilized continuous feedback and cyclic adjustments for program refinement.

Main Results:

  • Established a culture of trust and autonomy for student pharmacists.
  • Graduates are well-prepared for independent and team-based practice.
  • Entrustable Professional Activity (EPA) assessments show high skill ratings for students.

Conclusions:

  • A long-term, trust-based curricular framework fosters independent pharmacy practitioners.
  • Continuous adaptation of experiential education is key to meeting practice demands.
  • Graduates are equipped for current and future roles in pharmacy.