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Updated: Oct 26, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
12.4K
Squaring the circle: circRNAs in melanoma.
Nicol Mecozzi1, Olga Vera1, Florian A Karreth2
1Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Oncogene
|July 31, 2021
Summary
Circular RNAs (circRNAs) are key non-coding RNAs in melanoma development and treatment. This review explores circRNA functions, their role as tumor suppressors like CDR1as, and their potential in melanoma therapy.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Non-coding RNAs play crucial roles in cutaneous melanoma.
- Circular RNAs (circRNAs) are a distinct class of non-coding RNAs formed via back-splicing.
- Understanding circRNAs is vital for melanoma research.
Purpose of the Study:
- To review the features and functions of circRNAs.
- To summarize the current knowledge on circRNAs in melanoma.
- To discuss the potential of circRNAs in melanoma diagnosis and therapy.
Main Methods:
- Literature review of circRNAs in cutaneous melanoma.
- Analysis of circRNA mechanisms, focusing on CDR1as.
- Discussion of circRNAs as biomarkers and therapeutic strategies.
Main Results:
- CircRNAs are implicated in melanoma genesis, progression, and therapy resistance.
- The circRNA CDR1as functions as a melanoma tumor suppressor.
- CircRNAs show promise as melanoma biomarkers and therapeutic targets/agents.
Conclusions:
- CircRNAs are critical regulators in melanoma.
- Further research is needed to fully characterize circRNA functions and therapeutic potential.
- CircRNAs represent a promising avenue for novel melanoma treatments.
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