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Updated: Oct 26, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K

Squaring the circle: circRNAs in melanoma

Nicol Mecozzi1, Olga Vera1, Florian A Karreth2

  • 1Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Oncogene
|July 31, 2021
PubMed

Insights

Circular RNAs (circRNAs) are key non-coding RNAs in melanoma development and treatment. This review explores circRNA functions, their role as tumor suppressors like CDR1as, and their potential in melanoma therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-coding RNAs play crucial roles in cutaneous melanoma.
  • Circular RNAs (circRNAs) are a distinct class of non-coding RNAs formed via back-splicing.
  • Understanding circRNAs is vital for melanoma research.

Purpose of the Study:

  • To review the features and functions of circRNAs.
  • To summarize the current knowledge on circRNAs in melanoma.
  • To discuss the potential of circRNAs in melanoma diagnosis and therapy.

Main Methods:

  • Literature review of circRNAs in cutaneous melanoma.
  • Analysis of circRNA mechanisms, focusing on CDR1as.
  • Discussion of circRNAs as biomarkers and therapeutic strategies.

Main Results:

  • CircRNAs are implicated in melanoma genesis, progression, and therapy resistance.
  • The circRNA CDR1as functions as a melanoma tumor suppressor.
  • CircRNAs show promise as melanoma biomarkers and therapeutic targets/agents.

Conclusions:

  • CircRNAs are critical regulators in melanoma.
  • Further research is needed to fully characterize circRNA functions and therapeutic potential.
  • CircRNAs represent a promising avenue for novel melanoma treatments.

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