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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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Eosinophilic Gastritis/Gastroenteritis
Phillip H Chen1,2, Lorraine Anderson3, Kuixing Zhang4
1David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, suite 345, Los Angeles, CA, 90095, USA.
Current Gastroenterology Reports
|July 31, 2021
Summary
Eosinophilic gastritis/gastroenteritis (EG/EGE) are rare gastrointestinal disorders. Diagnosis requires high suspicion and biopsies, with corticosteroids as the primary treatment, though new therapies are emerging.
Area of Science:
- Gastroenterology
- Immunology
- Pediatrics
Background:
- Eosinophilic gastritis/gastroenteritis (EG/EGE) are rare eosinophilic gastrointestinal disorders (EGIDs).
- EGIDs encompass eosinophilic esophagitis (EoE) and eosinophilic colitis.
- These conditions involve eosinophilic infiltration of the gastrointestinal tract.
Purpose of the Study:
- Review current literature on EG/EGE.
- Detail clinical presentation, diagnostic criteria, and management.
- Highlight challenges and advancements in EG/EGE diagnosis and treatment.
Main Methods:
- Literature review of clinical presentation, diagnosis, and management of EG/EGE.
- Analysis of diagnostic criteria, including tissue and blood-based methods.
- Evaluation of current and emerging therapeutic interventions.
Main Results:
- Pathophysiology involves hypersensitivity; standardized diagnostic criteria are lacking for EG/EGE.
- Non-EoE EGIDs are harder to treat than EoE, with over a third achieving spontaneous remission.
- Corticosteroids are the mainstay; biologics and other agents show promise, with AK002 being a notable investigational therapy.
Conclusions:
- High suspicion and adequate biopsies are crucial for diagnosing EG/EGE in atopic patients.
- Corticosteroids are primary treatment, often long-term; steroid-sparing agents are experimental.
- Therapeutic goals are evolving beyond clinical remission, with histological remission lacking evidence.
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