Recent advances in, and challenges of, anti-angiogenesis agents for tumor chemotherapy based on vascular
Kai Wang1, Qinhua Chen2, Nanxin Liu1
1School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Abstract:
A major problem associated with cancer treatment is resistance-prone chemotherapeutic drugs. An increasing number of studies have documented that the occurrence of resistance tends to be associated with abnormal blood vessels. In 2001, Jain proposed the vascular normalization theory, which was recently applied to the drug-resistant treatment of tumors in the clinic. Through the intervention of angiogenesis inhibitors, remodeling the structure and function of abnormal vessels can maximize the efficacy of chemotherapeutic drugs. In this review, we systematically describe the occurrence and progress of tumor angiogenesis, as well as the pathological characteristics of tumor blood vessels. Moreover, druggable targets for vascular normalization and the development of related inhibitors are also outlined.
Insights
Cancer treatment faces challenges with drug resistance, often linked to abnormal tumor blood vessels. Vascular normalization strategies using angiogenesis inhibitors can improve chemotherapy efficacy by remodeling these vessels.
Area of Science:
- Oncology
- Vascular Biology
- Cancer Therapeutics
Background:
- Chemotherapeutic drug resistance is a significant obstacle in cancer treatment.
- Abnormal tumor vasculature is increasingly recognized as a key factor in drug resistance.
- Jain's vascular normalization theory (2001) offers a strategy to overcome this resistance.
Purpose of the Study:
- To review the progression and characteristics of tumor angiogenesis and abnormal tumor vasculature.
- To explore the concept of vascular normalization in the context of drug-resistant tumors.
- To identify druggable targets and inhibitors for vascular normalization.
Main Methods:
- Systematic review of scientific literature on tumor angiogenesis.
- Analysis of pathological characteristics of tumor blood vessels.
- Discussion of clinical applications of vascular normalization theory.
Main Results:
- Tumor angiogenesis leads to abnormal vessel structures that promote drug resistance.
- Vascular normalization aims to remodel these abnormal vessels to improve drug delivery and efficacy.
- Angiogenesis inhibitors are key therapeutic agents for vascular normalization.
Conclusions:
- Targeting tumor vasculature through normalization is a promising strategy to combat chemotherapy resistance.
- Understanding tumor angiogenesis and vessel pathology is crucial for developing effective vascular-targeting therapies.
- Further research into druggable targets and inhibitors will advance clinical applications of vascular normalization.
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