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Related Experiment Video

Updated: Oct 26, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Oral Mucosal Melanoma.

Marco Nisi1, Rossana Izzetti, Stefano Gennai

  • 1Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

The Journal of Craniofacial Surgery
|August 2, 2021
PubMed
Summary
This summary is machine-generated.

Primary oral mucosal melanoma (OMM) is a rare cancer. Early diagnosis is crucial as many cases present with advanced metastasis, indicating a poor prognosis.

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Area of Science:

  • Oncology
  • Oral Pathology

Background:

  • Primary oral mucosal melanoma (OMM) is a rare malignancy, comprising 0.2% to 0.8% of all melanomas.
  • OMM presents a diagnostic and therapeutic challenge due to its rarity and aggressive nature.

Purpose of the Study:

  • To present two cases of primary OMM treated at the authors' institution.
  • To conduct a systematic literature review on the occurrence and treatment of primary OMM.

Main Methods:

  • Detailed description of two primary OMM cases, including diagnosis and surgical management.
  • Systematic literature review to analyze treatment strategies, recurrence rates, metastasis, and survival in primary OMM.

Main Results:

  • Two patients with OMM of the hard palate and maxillary gingiva underwent biopsy and surgical resection.
  • Literature review identified 447 primary OMM cases; 30% had distant metastases at diagnosis.
  • Surgical treatment and adjuvant radiotherapy were the most common management approaches for primary OMM.

Conclusions:

  • Primary OMM diagnosis remains challenging, often occurring after metastasis development.
  • The generally poor prognosis underscores the urgent need for improved early diagnostic methods for OMM.