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Amadis: A Comprehensive Database for Association Between Microbiota and Disease.

Long Li1,2, Qingxu Jing1,2, Sen Yan3

  • 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Frontiers in Physiology
|August 2, 2021
PubMed
Summary

Researchers created Amadis, a database linking gut microbes and human diseases. This resource helps scientists understand complex microbiota-disease relationships from vast amounts of data.

Keywords:
bioinformaticsdatabasegut microbiotahuman diseasesnetwork

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Area of Science:

  • Microbiome research
  • Human-microbe interactions
  • Computational biology

Background:

  • The human gut microbiome plays a crucial role in host health and disease.
  • Multi-omics technologies have generated extensive data on microbial functions.
  • A need exists for consolidated, accessible information on microbiota-disease associations.

Purpose of the Study:

  • To develop a manually curated database of experimentally supported microbiota-disease associations.
  • To provide a dynamic network construction method for visualizing these relationships.
  • To offer a user-friendly resource for researchers studying the gut microbiome and human diseases.

Main Methods:

  • Manual curation of over 1000 articles.
  • Development of the Amadis database (http://gift2disease.net/GIFTED).
  • Implementation of a dynamic network construction method.

Main Results:

  • The Amadis database contains 20,167 associations between 221 human diseases and 774 gut microbes across 17 species.
  • Users can generate custom microbe-based human disease networks.
  • The database offers browsing, searching, and downloading functionalities.

Conclusions:

  • Amadis provides a valuable, curated resource for exploring gut microbiota and human disease connections.
  • The database facilitates a comprehensive understanding of complex host-microbe interactions.
  • It aims to support researchers in navigating large-scale microbiome data.