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Crosslink: An R Package for Network Visualization of Grouped Nodes
Di Liu1, Zhijie Bai2, Bing Liu2,3,4
1Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Frontiers in Genetics
|August 2, 2021
Summary
The crosslink R package offers flexible network visualization for grouped nodes in biomedical research. It simplifies creating complex diagrams with associated metadata and annotation graphs.
Area of Science:
- Bioinformatics
- Computational Biology
- Data Visualization
Background:
- Network visualization is crucial in biomedical research for understanding complex relationships.
- Existing tools may lack flexibility for visualizing grouped nodes with extensive metadata.
Purpose of the Study:
- To develop an R package, crosslink, for advanced network visualization of grouped nodes.
- To provide flexible functions for creating network diagrams with complex metadata.
Main Methods:
- Developed a CrossLink class for metadata storage and coordinate manipulation.
- Implemented affine and function mapping transformations for group-based coordinate adjustments.
- Integrated with ggplot2 for drawing connections, aesthetic mappings, and annotation graphs.
Main Results:
- The crosslink package enables the creation of various network layouts (row, column, arc, polygon, hive).
- It facilitates the visualization of grouped nodes with associated metadata and annotation graphs.
- Offers a user-friendly interface for complex network diagram generation.
Conclusions:
- The crosslink R package provides an easy-to-use solution for complex network visualization in biomedical research.
- It enhances the exploration of relationships in gene regulatory networks, drug-target interactions, and multi-omics data.
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