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Experimental research in topical psoriasis therapy (Review)
Diana Ana-Maria Nițescu1, Alina Mușetescu2,3, Maria Nițescu4
1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Experimental and Therapeutic Medicine
|August 2, 2021
Summary
Topical treatments for psoriasis show promise in animal models, with new natural and synthetic compounds, including vesicular systems, offering targeted effects and improved patient compliance for this common inflammatory skin disease.
Area of Science:
- Dermatologic pathology
- Inflammatory diseases
- Pharmacology
Background:
- Psoriasis is a prevalent inflammatory skin disease with therapeutic challenges.
- Topical therapy for psoriasis is trending due to patient compliance and targeted effects.
- Novel drug delivery systems are crucial for enhancing topical psoriasis treatment efficacy.
Purpose of the Study:
- To review recent literature on topical psoriasis therapy in animal models.
- To identify new therapeutic substances and formulations for psoriasis.
- To highlight the role of animal research in developing new topical psoriasis treatments.
Main Methods:
- Literature review conducted on PubMed.
- Search terms included Psoriasis, topical/local, therapy/treatment, and mice/rats.
- Inclusion period: June 27, 2019, to July 9, 2020.
Main Results:
- New substances investigated include lycopene, sodium butyrate, siRNAs, and thymoquinone.
- Advanced formulations like vesicular systems and nanocarrier gels were studied.
- Existing treatments like cyclosporine and methotrexate in new formulations were also reviewed.
Conclusions:
- Animal models are vital for advancing topical psoriasis treatment research.
- Vesicular systems demonstrate significant potential as effective vehicles for topical psoriasis therapy.
- Emerging therapies offer new avenues for managing this chronic dermatologic condition.
