Risk Factors for Developing Hidradenitis Suppurativa in Patients With Inflammatory Bowel Disease: A Retrospective...

Area of Science:

• Dermatology
• Gastroenterology
• Clinical Research

Background:

• Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
• HS is known to be associated with inflammatory bowel disease (IBD).
• Risk factors for HS development in IBD patients require further elucidation.

Purpose of the Study:

• To characterize hidradenitis suppurativa (HS) within a cohort of inflammatory bowel disease (IBD) patients.
• To identify specific risk factors associated with the development of HS in individuals with IBD.

Main Methods:

• Retrospective case-control study conducted at an ambulatory IBD center.
• Cases of IBD with HS were matched 5:1 to controls with IBD but without HS.
• Conditional logistic regression analysis was employed to determine odds ratios (ORs) and 95% confidence intervals (95% CIs).

Main Results:

• The study included 29 HS cases and 145 controls.
• Patients with HS and IBD were significantly more likely to be current or past smokers (OR 10.3 and 8.4, respectively).
• Active endoscopic disease (OR 3.8) and active perianal disease in Crohn's disease patients (OR 21.1) were also associated with HS.

Conclusions:

• Active IBD, presence of perianal disease, and smoking history are potential risk factors for HS in IBD patients.
• These findings suggest a potential link between specific IBD disease characteristics and HS development.
• Further research with larger cohorts is recommended to better understand and manage this comorbidity.