Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

86.3K
Overview
86.3K
The Extracellular Matrix01:29

The Extracellular Matrix

10.2K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
10.2K
Extracellular Matrix01:26

Extracellular Matrix

4.1K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
4.1K
Liver Regeneration01:24

Liver Regeneration

3.5K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.5K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

346
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
346
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.7K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-term mortality is reduced and low grade ACLF reversed by TIPS in patients with fluid overload: a case-control study.

Clinical and translational gastroenterology·2026
Same author

Meteorological Dependencies in Ducks: Influence of Weather on Sex Ratio Bias and Hatchability.

Animal science journal = Nihon chikusan Gakkaiho·2026
Same author

Conversion to LCP Tacrolimus Mitigates Calcineurin-Induced Nephrotoxicity in Patients After Liver Transplantation.

Clinical transplantation·2026
Same author

Role of Gram-Negative Bacterial Infections in Acute-On-Chronic Liver Failure.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Corrigendum to "Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney" [Matrix Biology 68-69 (2018) 293-317].

Matrix biology : journal of the International Society for Matrix Biology·2026
Same author

Corrigendum to "Clustering of unhealthy lifestyle behaviors, self-rated health and disability" [Preventive Medicine 55 (2022) 106911].

Preventive medicine·2026

Related Experiment Video

Updated: Oct 26, 2025

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
06:46

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

Published on: February 25, 2022

2.0K

Extracellular Matrix Remodeling in Chronic Liver Disease.

Cristina Ortiz1, Robert Schierwagen1, Liliana Schaefer2

  • 1Translational Hepatology, Department of Internal Medicine I, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

Current Tissue Microenvironment Reports
|August 2, 2021
PubMed
Summary

Hepatic fibrosis involves excessive extracellular matrix accumulation, primarily collagens. This process is driven by activated hepatic stellate cells, altering liver structure and function.

Keywords:
CollagenExtracellular matrixHepatic stellate cellLiver fibrosisMetalloproteinasesTGF-β1

More Related Videos

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
05:20

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Published on: June 29, 2021

3.2K
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

12.0K

Related Experiment Videos

Last Updated: Oct 26, 2025

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
06:46

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

Published on: February 25, 2022

2.0K
Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
05:20

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Published on: June 29, 2021

3.2K
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

12.0K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Hepatology

Background:

  • The extracellular matrix (ECM) is crucial for cellular structure, signaling, and growth factor regulation.
  • Hepatic fibrosis is characterized by aberrant ECM accumulation in the liver.

Purpose of the Study:

  • To review current knowledge on ECM remodeling in hepatic fibrosis.
  • To explore cellular interactions and molecular mechanisms governing ECM changes during liver fibrosis.

Main Methods:

  • Literature review of studies on hepatic fibrosis and ECM.
  • Analysis of molecular pathways regulating ECM deposition and degradation.

Main Results:

  • The ECM provides structural support and mediates cell behavior through adhesion signals and sequestered factors.
  • Hepatic fibrosis involves excessive deposition of ECM components, predominantly collagens.

Conclusions:

  • Hepatic fibrosis results from dysregulated ECM remodeling and excessive accumulation of matrix components.
  • Activated hepatic stellate cells, the primary source of ECM, are key players in fibrogenesis, driven by ECM-derived signals.