Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.0K
Development of Blood Vessels01:07

Development of Blood Vessels

1.1K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
1.1K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.2K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.2K
Overview of the Vascular System01:20

Overview of the Vascular System

3.2K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pannexin-1 is present in a subpopulation of bovine milk-derived small extracellular vesicles.

Cell and tissue research·2026
Same author

Exploring the neurological impact of prematurity: Shared mechanisms in periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH), and hydrocephalus.

Early human development·2025
Same author

ChatGPT-4 in Neurosurgery: Improving Patient Education Materials.

Neurosurgery·2025
Same author

A single-center study of the RED 72 reperfusion catheter with SENDit technology in proximal large vessel occlusions.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2025
Same author

Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives.

The Journal of physiology·2025
Same author

Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides for Targeted Cardiac Ischemia-Reperfusion Therapy.

bioRxiv : the preprint server for biology·2025
Same journal

The Vasculature in Pulmonary Fibrosis.

Current tissue microenvironment reports·2023
Same journal

Extracellular Matrix Remodeling in Chronic Liver Disease.

Current tissue microenvironment reports·2021
Same journal

Biomechanical Regulation of Hematopoietic Stem Cells in the Developing Embryo.

Current tissue microenvironment reports·2021
Same journal

Biophysical and epigenetic regulation of cancer stemness, invasiveness and immune action.

Current tissue microenvironment reports·2021
Same journal

The role of pericytes in hyperemia-induced capillary de-recruitment following stenosis.

Current tissue microenvironment reports·2021
Same journal

Development of novel microenvironments for promoting enhanced wound healing.

Current tissue microenvironment reports·2021
See all related articles

Related Experiment Video

Updated: Nov 12, 2025

Incorporating Pericytes into an Endothelial Cell Bead Sprouting Assay
06:21

Incorporating Pericytes into an Endothelial Cell Bead Sprouting Assay

Published on: February 16, 2018

8.4K

Pericytes in Vascular Development.

Laura Beth Payne1, Maruf Hoque1,2, Clifton Houk3,4

  • 1Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech-Carilion, Roanoke, VA 24016, USA.

Current Tissue Microenvironment Reports
|March 22, 2021
PubMed
Summary
This summary is machine-generated.

Pericytes are crucial for blood vessel stability and formation. New research highlights their collaborative roles with endothelial cells in vascular development, including vessel pruning and regrowth.

Keywords:
angiogenesisendothelial cellmural cell differentiationpericytevascular developmentvasculogenesis

More Related Videos

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.4K
In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse
08:16

In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse

Published on: December 19, 2016

9.9K

Related Experiment Videos

Last Updated: Nov 12, 2025

Incorporating Pericytes into an Endothelial Cell Bead Sprouting Assay
06:21

Incorporating Pericytes into an Endothelial Cell Bead Sprouting Assay

Published on: February 16, 2018

8.4K
Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.4K
In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse
08:16

In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse

Published on: December 19, 2016

9.9K

Area of Science:

  • Vascular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • Pericytes are integral to capillary stability and integrity.
  • Their roles in microvascular function are continually being uncovered.
  • Understanding pericyte differentiation is key to early vessel formation.

Purpose of the Study:

  • To review foundational and current studies on pericyte differentiation mechanics.
  • To elucidate the roles of pericytes in the earliest stages of vessel formation.

Main Methods:

  • Review of current and foundational scientific literature.
  • Analysis of pericyte-focused tools and models.
  • Synthesis of data on pericyte interactions with endothelial cells.

Main Results:

  • Advances in pericyte research illuminate their roles in vascular development.
  • Pericytes collaborate with endothelial cells in vasculogenesis, sprouting, and intussusceptive angiogenesis.
  • Pericytes regulate vascular growth, including pruning, rarefaction, and regrowth.

Conclusions:

  • Pericytes are essential regulators of vascular development and function.
  • Their interactions with endothelial cells are critical for forming and maintaining blood vessels.
  • Further research into pericyte biology will advance understanding of microvascular health and disease.