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Pragmatic patient engagement in designing pragmatic oncology clinical trials

Bernard Bright Davies-Teye1,2, Michelle Medeiros1,2, Cynthia Chauhan2

  • 1Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.

Future Oncology (London, England)
|August 2, 2021
PubMed

Insights

This study offers practical guidance for designing pragmatic and patient-centered oncology trials. Implementing tools like PRECIS-2 and the 10-Step Engagement Framework can improve trial participation and efficiency.

Area of Science:

  • Clinical Trials
  • Oncology Research
  • Patient-Centered Care

Background:

  • Oncology trials are crucial for therapeutic advancements but face increasing demands for pragmatism and patient engagement.
  • Researchers often lack clear strategies for enhancing trial practicality and meaningful patient involvement while maintaining scientific rigor.

Purpose of the Study:

  • To provide practical guidance for making oncology trials more pragmatic and patient-centered.
  • To address researcher uncertainty regarding the integration of patient engagement without compromising scientific standards.

Main Methods:

  • Utilized evidence-based approaches, specifically the PRECIS-2 tool.
  • Applied the 10-Step Engagement Framework for practical implementation guidance.

Main Results:

  • The proposed methods offer a structured approach to enhance trial design and execution.
  • Patient-centered oncology trials demonstrated improvements in participation, recruitment speed, and patient retention.

Conclusions:

  • The PRECIS-2 tool and 10-Step Engagement Framework provide actionable strategies for pragmatic, patient-centered oncology trials.
  • Implementing these approaches can lead to wider adoption of innovative cancer therapies in community settings.
Keywords:
10-Step Engagement Frameworkdiversity in trialspatient engagementpatient-centered trialspragmatic clinical trials

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