Single Photon Emission Computed Tomography/Positron Emission Tomography Molecular Imaging for Parkinsonism: A
Antoine Verger1,2, Stephan Grimaldi3, Maria-Joao Ribeiro4
1Department of Nuclear Medicine & Nancyclotep Imaging Platform, Centre Hospitalier Régional Universitaire Nancy, Lorraine University, Nancy, France.
Abstract:
The early differential diagnosis of Parkinson disease and atypical parkinsonism is a major challenge. The use of single photon emission computed tomography (SPECT)/positron emission tomography (PET) molecular imaging to investigate parkinsonism is a fast-developing field. Imaging biomarker research may potentially lead to more accurate disease detection, enabling earlier diagnosis and treatment. This review summarizes recent SPECT/PET advances in radiopharmaceuticals and imaging technologies/analyses that improve the diagnosis of neurodegenerative parkinsonism. We are currently witnessing a turning point in the field. Integrating molecular imaging as a diagnostic technique represents an opportunity to reassess the strategies for diagnosing neurodegenerative parkinsonism. ANN NEUROL 2021;90:711-719.
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