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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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Related Experiment Video

Updated: Jul 8, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing ¹⁸F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

How Fluorine-18-labeled Fluorodeoxyglucose PET Changed Clinical Practice in Central Nervous System Disorders.

Eric Guedj¹, Andrew B Newberg², Abass Alavi³

¹Aix Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Nuclear Medicine Department, Marseille, France.

|July 6, 2026

Summary

Fluorine-18-labeled fluorodeoxyglucose (FDG) PET imaging offers vital insights into brain metabolism for diagnosing central nervous system disorders. This technique provides reliable biomarkers crucial for improving diagnostic accuracy and patient management in neurology.

Keywords:

Autoimmune encephalitis Biomarkers Brain metabolism Central nervous system Epilepsy Neurodegenerative disorders Neuroimaging [18F]FDG PET

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

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Last Updated: Jul 8, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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Published on: July 21, 2018

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Area of Science:

Neurology
Nuclear Medicine
Biomarker Discovery

Background:

Fluorine-18-labeled fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) has been utilized for over five decades.
It enables in vivo assessment of brain metabolism, serving as a surrogate for functional integrity in the central nervous system (CNS).

Purpose of the Study:

To highlight the transformative role of [18F]FDG PET in clinical practice for CNS disorders.
To emphasize its utility beyond structural imaging by providing pattern-based biomarkers.

Main Methods:

Utilizing [18F]FDG PET to assess brain metabolism.
Application of standardized methodologies and analytical approaches.

Main Results:

[18F]FDG PET provides reproducible, pattern-based biomarkers.
These biomarkers enhance diagnostic accuracy in conditions such as dementia, epilepsy, and neuroinflammatory diseases.
[18F]FDG PET captures downstream network dysfunction and disease phenotype.

Conclusions:

[18F]FDG PET remains a cornerstone in the evolving landscape of neurological biomarkers.
It is essential for differential diagnosis, prognostic assessment, and precision neurology.
Standardized methods and advanced analytics support its central role in managing CNS disorders.