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Updated: Oct 26, 2025
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Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes
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Oocyte quality and aging.
Ali Reza Eftekhari Moghadam1,2, Mahin Taheri Moghadam2, Masoud Hemadi2
1Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
JBRA Assisted Reproduction
|August 2, 2021
Summary
Female reproductive ability declines with age due to decreased oocyte quality and quantity. This review explores factors affecting oocyte aging and potential strategies to improve fertility outcomes for older women.
Area of Science:
- Reproductive biology
- Gerontology
- Cellular biology
Background:
- Female fertility significantly declines in the fourth decade of life.
- Increased numbers of women aged 36-44 are seeking conception.
- Causes of reproductive aging and its physiological mechanisms remain unclear.
Purpose of the Study:
- To review current evidence on the impact of aging on oocyte quality and female reproductive capacity.
- To investigate the physiological aspects of reproductive aging.
- To identify factors influencing oocyte quality and female infertility.
Main Methods:
- Literature review of existing data on reproductive aging.
- Analysis of factors contributing to decreased oocyte quality with advanced maternal age.
- Focus on ovarian follicle environment, oocyte structure, and organelles.
Main Results:
- Oocyte quality and quantity demonstrably decrease with advancing female age.
- Assisted Reproductive Technologies (ART) show reduced oocyte yield and quality in older women.
- Increased aneuploidy, spindle disruption, oxidative stress, and mitochondrial damage are implicated.
Conclusions:
- Aging negatively impacts oocyte quality, leading to reduced female reproductive success.
- Further research is needed to understand the complex factors causing reduced oocyte quality.
- Optimizing oocyte quality is crucial for improving clinical outcomes in aging women facing infertility.
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