Related Experiment Video
Updated: Oct 26, 2025
08:36
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
Published on: August 8, 2019
12.2K
Exploiting circadian memory to hasten recovery from circadian misalignment
1Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, Knoxville, Tennessee 37996, USA.
Chaos (Woodbury, N.Y.)
|August 3, 2021
Summary
This study introduces a novel approach to combat jet lag by incorporating circadian memory into reentrainment strategies. By leveraging amplitude coordinates, we can prime the body
Area of Science:
- Chronobiology and Dynamical Systems
- Mathematical Modeling of Biological Systems
- Computational Neuroscience
Background:
- Jet lag disrupts the body's internal clock, leading to negative health effects.
- Current circadian reentrainment strategies often simplify models by neglecting amplitude dynamics.
- Amplitude coordinates, representing memory effects, are crucial for a complete understanding of circadian rhythms.
Purpose of the Study:
- To develop improved jet lag amelioration strategies by incorporating circadian memory.
- To investigate the role of amplitude coordinates in circadian reentrainment.
- To identify a latent phase shift for faster reentrainment to new time zones.
Main Methods:
- Utilized an operational phase and isostable coordinate framework to analyze circadian models.
- Focused on amplitude coordinates to capture memory effects from past environmental inputs.
- Employed data-driven model identification for reduced-order, phase-amplitude models when equations are unknown.
Main Results:
- Identified a latent phase shift that primes the circadian cycle for more rapid reentrainment.
- Developed an optimal control strategy balancing control effort with the desired latent phase shift.
- Demonstrated the effectiveness of the phase-amplitude model in both simple and coupled oscillator systems.
Conclusions:
- Accounting for circadian memory through amplitude coordinates significantly enhances reentrainment strategies.
- The proposed latent phase shift offers a promising method for mitigating jet lag effects.
- Phase-amplitude models provide a powerful tool for understanding and manipulating circadian dynamics, even with unknown underlying equations.
Related Concept Videos
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
171
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
171
02:19Circadian Rhythms and Gene Regulation
4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
01:19Management of Insomnia
354
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
354
01:13Insufficient Sleep and Sleep Deprivation
339
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
339
01:11Understanding Sleep
852
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
852
02:45Biological Clocks and Seasonal Responses
39.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
39.8K