Three-dimensional numerical analysis as a tool for optimization of acoustophoretic separation in polymeric chips
Elena de Los Reyes1, Victor Acosta1, Pilar Carreras2
1Group of Ultrasonic Resonators RESULT, Department of Sensors and Ultrasonic Systems, Institute of Physical Technologies and Information (ITEFI), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28006, Spain.
The Journal of the Acoustical Society of America
|August 3, 2021
Summary
This study introduces 3D numerical analysis for optimizing polymeric chips used in acoustophoretic separation. This method enables efficient particle and cell separation using whole-structure resonances in soft materials.
Area of Science:
- Biomedical Engineering
- Acoustic Technology
- Materials Science
Background:
- Polymeric separators utilizing acoustophoretic separation have been developed since 2010 for efficient particle and cell separation.
- These separators rely on three-dimensional (3D) resonances of the entire structure actuated by ultrasound.
Purpose of the Study:
- To present and validate a numerical 3D analysis as a tool for optimizing polymeric chips for acoustophoretic separation.
- To explore the use of acoustically soft materials enabled by whole-structure resonances, contrasting with conventional rigid materials.
Main Methods:
- Development and validation of a numerical 3D analysis for polymeric acoustophoretic separation chips.
- Investigation of whole-structure resonances in polymeric materials for acoustic manipulation.
Main Results:
- The 3D numerical analysis is validated as an essential tool for optimizing polymeric chip design.
- Whole-structure resonances allow the use of acoustically soft, low-impedance materials, suitable for biological samples.
- This approach offers advantages in design, manufacturing, and cost-effectiveness, including potential for printed devices.
Conclusions:
- 3D numerical analysis is crucial for understanding and optimizing the complex resonances in polymeric acoustophoretic chips.
- The validated analysis facilitates the efficient acoustophoretic separation of particles and cells in suspensions using advanced polymeric materials.
