Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement

Area of Science:

• Oncology
• Genetics
• Urology

Background:

• Hereditary factors significantly contribute to renal cell carcinoma (RCC) development.
• Existing guidelines for genetic risk assessment in RCC are lacking.
• Clinicians face challenges in identifying patients needing genetic evaluation for hereditary kidney cancer.

Purpose of the Study:

• To gauge expert opinion on genetic risk assessment for hereditary RCC.
• To develop consensus statements guiding clinicians in evaluating patients with suspected hereditary kidney cancer.
• To address the need for standardized genetic risk assessment protocols in RCC.

Main Methods:

• A North American multidisciplinary expert panel was convened.
• Modified Delphi methodology was employed to generate and refine consensus questions.
• Uniform consensus was defined as ≥85% agreement among panelists.

Main Results:

• Thirty-three experts, including urologists, oncologists, and geneticists, participated.
• Uniform consensus was achieved on 30 statements regarding RCC genetic risk assessment.
• Key areas of agreement included family history criteria, risk assessment for specific disease presentations, multigene panel utility, and counseling acceptance.

Conclusions:

• The first consensus panel on hereditary RCC genetic risk assessment reached 30 statements.
• These statements offer guidance for clinicians evaluating patients for hereditary kidney cancer.
• Further research and discussion are needed, with a future meeting planned.