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Updated: Oct 25, 2025

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
[Acute kidney injury - Update 2021].
Kai M Schmidt-Ott1,2,3
1Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin.
Acute kidney injury (AKI) affects 20% of hospitalized patients, increasing mortality and chronic kidney disease risk. This review covers AKI detection, renal replacement therapy, and COVID-19 associated AKI.
Area of Science:
- Nephrology
- Critical Care Medicine
- Health Informatics
Background:
- Acute kidney injury (AKI) impacts 20% of hospitalized patients, significantly raising mortality risks (up to 15-fold).
- AKI is a critical risk factor for developing chronic kidney disease and experiencing cardiovascular events.
- Understanding recent advancements in AKI management and detection is crucial for improving patient outcomes.
Purpose of the Study:
- To review recent studies on automated AKI detection using electronic health records (EHRs).
- To summarize current knowledge on renal replacement therapy (RRT), including optimal timing and anticoagulation.
- To discuss findings related to acute kidney injury associated with coronavirus disease 2019 (COVID-19).
Main Methods:
- Literature review of recently published studies.
- Focus on studies employing electronic health records-based alert systems for AKI detection.
- Analysis of research on renal replacement therapy protocols and COVID-19 associated AKI.
Main Results:
- Electronic health records-based alert systems show promise for automated AKI detection.
- Optimal timing and anticoagulation regimens for renal replacement therapy are areas of ongoing research.
- Coronavirus disease 2019 is frequently associated with acute kidney injury, requiring specific clinical considerations.
Conclusions:
- Automated AKI detection systems can enhance early identification and intervention.
- Further research is needed to refine renal replacement therapy strategies.
- Managing COVID-19 associated AKI requires tailored approaches within critical care settings.
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