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Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
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[Topical NSAIDs: ineffective or undervalued?]

Noortje van Herwaarden1,2, Geke A H van den Elsen3, Ingrid C A de Jong3

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Summary
This summary is machine-generated.

Topical non-steroidal anti-inflammatory drugs (NSAIDs) are effective for osteoarthritis and acute pain, offering a safer alternative to oral NSAIDs. Diclofenac gel is a recommended option.

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Area of Science:

  • Pharmacology
  • Rheumatology
  • Pain Management

Background:

  • Topical NSAIDs are recommended for osteoarthritis and acute pain but face skepticism.
  • Understanding their pharmacokinetics and pharmacodynamics is crucial.
  • Evidence for efficacy and safety is available.

Purpose of the Study:

  • To address skepticism surrounding topical NSAIDs.
  • To review evidence on the efficacy and safety of topical NSAIDs.
  • To compare topical NSAIDs with oral NSAIDs.

Main Methods:

  • Literature review of pharmacokinetic and pharmacodynamic data.
  • Analysis of clinical trial evidence for topical NSAID efficacy and safety.
  • Guideline review for topical NSAID recommendations.

Main Results:

  • Topical NSAIDs demonstrate clear efficacy in knee and hand osteoarthritis and acute musculoskeletal pain.
  • They offer a favorable safety profile with fewer systemic side effects compared to oral NSAIDs.
  • Topical NSAIDs are suitable for patients with contraindications to oral NSAIDs.

Conclusions:

  • Topical NSAIDs are a valuable treatment option for osteoarthritis and acute pain.
  • They should be considered before oral NSAIDs due to improved safety.
  • Diclofenac gel is a sensible choice among available topical NSAIDs in the Netherlands.