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Mesenchymal Stem Cells: From Regeneration to Drug Delivery Systems

Zeeshan Shokat1, Abdaal Ali1, Uzair Ahmed2

  • 1Department of Bioinformatics and Biotechnology, Government College University, Faisalabad (GCUF), Allama Iqbal Road, Faisalabad-38000, Pakistan.

Critical Reviews in Therapeutic Drug Carrier Systems
|August 4, 2021
PubMed

Insights

Mesenchymal stem cells (MSCs) offer a promising cell-based alternative for targeted drug delivery, overcoming limitations of traditional methods. This research explores MSCs

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Oncology

Background:

  • Targeted drug delivery is crucial for treating cancer and other diseases.
  • Existing methods like liposomes and nanoparticles have limitations for clinical use.
  • Cell-based drug delivery systems present a novel therapeutic alternative.

Purpose of the Study:

  • To explore the potential of mesenchymal stem cells (MSCs) as drug delivery vehicles.
  • To discuss the challenges and opportunities associated with using MSCs for therapeutic drug delivery.
  • To highlight MSCs' unique properties for targeted delivery applications.

Main Methods:

  • Review of existing literature on cell-based drug delivery systems.
  • Analysis of mesenchymal stem cells' characteristics relevant to drug delivery.
  • Identification of challenges and opportunities in MSC-mediated drug delivery.

Main Results:

  • Mesenchymal stem cells (MSCs) possess key characteristics for drug delivery, including low immunogenicity and tumor-homing abilities.
  • MSCs can be engineered to carry and deliver therapeutic agents to specific sites.
  • Challenges remain in optimizing MSC-based delivery for widespread clinical application.

Conclusions:

  • Mesenchymal stem cells (MSCs) represent a viable and advantageous platform for targeted drug delivery.
  • Further research and development are needed to overcome challenges and fully realize the clinical potential of MSC-based therapies.
  • MSCs offer a promising future for enhanced therapeutic efficacy and reduced side effects in various ailments.

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