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Updated: Oct 25, 2025
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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
Published on: June 11, 2015
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Hostile Takeover: How Viruses Reprogram Prokaryotic Metabolism.
Tyler B Jacobson1,2,3, Melanie M Callaghan1,3, Daniel Amador-Noguez1,2,3
1Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA; email: tbjacobson@wisc.edu, callaghan2@wisc.edu, amadornoguez@wisc.edu.
Annual Review of Microbiology
|August 4, 2021
Summary
Prokaryotic viruses reprogram host metabolism to produce new virus particles. This review covers recent findings on viral metabolic reprogramming and suggests systems biology approaches for understanding this process during infection.
Area of Science:
- Microbiology
- Virology
- Systems Biology
Background:
- Prokaryotic viruses require host cellular machinery for replication.
- Viral infection involves hijacking host replication and protein synthesis.
- Recent evidence highlights extensive reprogramming of host primary metabolism by viruses.
Purpose of the Study:
- To review recent findings on virus-induced reprogramming of prokaryotic metabolism.
- To explore the role of metabolic reprogramming in virion production.
- To suggest systems biology approaches for understanding metabolic remodeling during lytic viral infection.
Main Methods:
- Literature review of recent studies on viral metabolic reprogramming.
- Discussion of findings related to prokaryotic virus-host metabolic interactions.
- Proposal of quantitative systems biology approaches.
Main Results:
- Extensive reprogramming of host primary metabolism is a widespread phenomenon in prokaryotic virus infections.
- Metabolic reprogramming is essential for meeting the biosynthetic demands of virion production.
- Virus-induced metabolic changes are crucial for successful viral replication.
Conclusions:
- Virus-induced metabolic reprogramming is a critical aspect of the viral life cycle.
- Quantitative systems biology offers a promising avenue for a holistic understanding of these metabolic changes.
- Further research integrating systems biology is needed to fully elucidate metabolic remodeling during lytic infection.
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