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Updated: Oct 25, 2025

Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
Brain Developmental Trajectories in Children and Young Adults with Isolated Cleft Lip and/or Cleft Palate
Emily Kuhlmann1, Ellen van der Plas2, Eric Axelson2
1Department of Psychological and Quantitative Foundations, University of Iowa College of Education, USA.
Abstract:
The present study evaluated brain development in persons with isolated cleft lip and/or cleft palate (iCL/P) compared to unaffected controls using an accelerated longitudinal design. A sample of 134 males and females, ages 7-27 years, with iCL/P (184 observations, total) was compared to 144 unaffected controls (208 evaluations, total) on Wechsler Index scores and volumetric data from structural MRI scans. Boys with isolated cleft palate had verbal IQ 15.5 points lower than perceptual IQ; a clinically significant difference. Participants with iCL/P had differential growth trajectories of regional cerebrum matter and consistently lower volumes of cerebellar gray matter and subcortical matter.
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