Related Experiment Video
Updated: Oct 25, 2025

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
CD36 pumps fat to defang killer T cells in tumors
Manikandan Subramanian1, Federica M Marelli-Berg1
1Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Abstract:
The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma et al. (2021) in Cell Metabolism and Xu et al. (2021) in Immunity that describe a key role of T cell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ T cell dysfunction, ferroptosis, and reduced anti-tumor function.
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