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P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
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Advances in pulmonary drug delivery targeting microbial biofilms in respiratory diseases

Ankur Sharma1, Dhruv Kumar2, Kajal Dahiya1

  • 1Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida, 201310, India.

Nanomedicine (London, England)
|August 5, 2021
PubMed

Insights

This review explores bacterial biofilms in respiratory infections, highlighting current treatments and the potential of nanocarriers. It discusses challenges and strategies for effective biofilm disruption in pulmonary infections.

Area of Science:

  • Microbiology
  • Pulmonary Medicine
  • Nanotechnology

Background:

  • Microbial biofilms significantly contribute to the global burden of respiratory diseases.
  • Bacterial biofilms in the respiratory tract cause persistent and difficult-to-treat pulmonary infections.

Purpose of the Study:

  • To review the types of bacterial biofilms affecting the respiratory system.
  • To examine current treatment strategies for pulmonary biofilm infections.
  • To discuss the potential and challenges of nanocarrier-based therapies for biofilm disruption.

Main Methods:

  • Literature review of studies on respiratory biofilms.
  • Analysis of existing treatment modalities for pulmonary infections.
  • Exploration of nanocarrier applications in drug delivery for biofilm eradication.

Main Results:

  • Bacterial biofilms present unique challenges in treating respiratory infections.
  • Nanocarrier-based drug delivery systems show promise for enhanced biofilm disruption.
  • Overcoming challenges in nanocarrier delivery is crucial for therapeutic success.

Conclusions:

  • Effective treatment of pulmonary biofilm infections requires innovative strategies.
  • Nanoparticle-based approaches offer a promising avenue for future therapeutic development.
  • Further research into biofilm mechanisms and nanocarrier systems is essential for advancing pulmonary infection treatment.
Keywords:
bacterial biofilmbiofilmdrug deliverynanocarrierspulmonary infectionsystemic therapy

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