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Published on: April 1, 2019
A meta-analysis for association of TNF-α -308G>A polymorphism with susceptibility to Ankylosing Spondylitis
Masoud Mahdinejad-Yazdi1, Mohammad Reza Sobhan1, Seyed Alireza Dastgheib2
1Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Objective:
We performed a meta-analysis of all eligible studies on the association of TNF-α -308G>A polymorphism with risk of Ankylosing spondylitis (AS).
Methods:
A comprehensive literature research was performed in online databases.
Results:
A total of 28 studies with 4489 cases and 5919 controls were included. Pooled ORs showed a significant association between TNF-α -308G>A polymorphism and risk of AS. Moreover, stratified analysis by ethnicity showed a significant association between TNF-α -308G>A polymorphism and AS risk in Asians, Caucasians and Mixed populations, but not in Chinese population.
Conclusion:
This meta-analysis suggested that the TNF-α -308G>A polymorphism was associated with AS risk.
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