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Ghost cell.

Snehal Uttam Chavhan1, Sonal S Dhanawade1, Chetan Fukate1

  • 1Department of Oral Pathology, Nair Hospital Dental College, Mumbai, Maharashtra, India.

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|August 5, 2021
PubMed
Summary
This summary is machine-generated.

Ghost cells (GCs), also known as shadow cells, are distinctive epithelial cells with a pale, translucent appearance. This article details their origin, microscopic features, staining properties, and diagnostic significance.

Keywords:
Masson's trichrome stainghost cellhematoxylin and eosinshadow celltranslucent cellvan Gieson stain

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Area of Science:

  • Histopathology
  • Cell Biology
  • Epithelial Cell Morphology

Background:

  • Ghost cells (GCs) are characterized by their unique morphology, appearing balloon-shaped with pyknotic nuclei and a pale, eosinophilic cytoplasm.
  • These cells are also referred to as shadow cells or translucent cells due to their faint outline in routine Hematoxylin and Eosin (H&E) staining.
  • The formation and precise characteristics of GCs have been a subject of ongoing scientific inquiry.

Purpose of the Study:

  • To provide a comprehensive description of ghost cells (GCs).
  • To elucidate the origin, microscopic appearance, and staining properties of GCs.
  • To detail the immunohistochemistry profile and diagnostic importance of GCs.

Main Methods:

  • Review of existing literature on ghost cells.
  • Analysis of histological features observed in H&E stained tissue samples.
  • Examination of immunohistochemical markers associated with GCs.

Main Results:

  • Detailed description of GC morphology: balloon-shaped, elliptical, pale eosinophilic epithelial cells with pyknotic nuclei.
  • Observation of the characteristic 'shadowy' or 'translucent' appearance in H&E staining.
  • Summary of immunohistochemical findings relevant to GC identification and origin.

Conclusions:

  • Ghost cells possess distinct morphological and staining characteristics.
  • Understanding GC features is crucial for accurate histopathological diagnosis.
  • Further research into GC origin and function may yield significant insights.