Factors Affecting Artificial Insemination Pregnancy Outcome

Area of Science:

• Reproductive Medicine
• Infertility Treatment
• Clinical Obstetrics and Gynecology

Background:

• Intrauterine insemination (IUI) is a common infertility treatment.
• Identifying factors influencing IUI clinical pregnancy outcomes is crucial for optimizing treatment success.

Purpose of the Study:

• To investigate key factors associated with clinical pregnancy outcomes in intrauterine insemination (IUI).
• To determine the impact of various parameters on the success rates of IUI procedures.

Main Methods:

• Retrospective analysis of 3984 IUI cycles from 1862 couples undergoing infertility treatment.
• Comparison of clinical pregnancy rates based on female/male age, endometrial thickness (EMT), post-wash total motile sperm count (PTMC), insemination timing, frequency, and ovarian stimulation protocols.

Main Results:

• Significant differences in clinical pregnancy rates were observed concerning female/male age, EMT, insemination timing, frequency, and ovarian stimulation protocols (p < 0.05).
• Ovarian stimulation (21.2%) and double IUI (17.8%) showed significantly higher clinical pregnancy rates than natural cycles (11.6%) and single IUI (12.1%), respectively (p < 0.01).
• Endometrial thickness (EMT) was significantly greater in the pregnant group (p < 0.05), while PTMC did not show a statistically significant impact on pregnancy rates.

Conclusions:

• Clinical pregnancy rates in IUI are significantly influenced by female/male age, EMT, insemination timing, frequency, and ovarian stimulation protocols.
• Ovarian stimulation protocols and double IUI procedures can markedly enhance clinical pregnancy outcomes in patients undergoing IUI.