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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Liquorice for pain?

Rae F Bell1, Vânia M Moreira2, Eija A Kalso3

  • 1(Emerita) Regional Centre of Excellence in Palliative Care, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.

Therapeutic Advances in Psychopharmacology
|August 5, 2021
PubMed
Summary
This summary is machine-generated.

Liquorice contains compounds like glycyrrhizin with anti-inflammatory and other properties, suggesting potential as a novel analgesic. Further research is needed to establish liquorice-derived compounds as effective pain management therapies.

Keywords:
glycyrrhizininflammationliquoricepain

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Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Pain Management

Background:

  • Liquorice (Glycyrrhiza glabra) has a long history of use in traditional medicine.
  • The plant contains bioactive compounds, notably glycyrrhizin, known for various pharmacological effects.
  • These include anti-inflammatory, antioxidant, antiviral, anticancer, hepatoprotective, and neuroprotective properties.

Purpose of the Study:

  • To review the potential of liquorice constituents as novel analgesics.
  • To explore the mechanisms of action for liquorice-derived anti-inflammatory effects.
  • To assess the therapeutic prospects of liquorice in pain management.

Main Methods:

  • Review of preclinical studies and traditional medicine literature.
  • Analysis of the pharmacological properties of liquorice constituents, including glycyrrhizin and its metabolites.
  • Examination of proposed mechanisms of anti-inflammatory action, such as HMGB1 inhibition and receptor antagonism.

Main Results:

  • Liquorice constituents exhibit broad bioactivities, including potent anti-inflammatory effects.
  • Mechanisms involve HMGB1 inhibition, gap junction blockade, and α2A-adrenoceptor antagonism.
  • Preclinical evidence and traditional use suggest potential for pain management.

Conclusions:

  • Liquorice-derived compounds possess multiple properties relevant to pain relief.
  • While promising, clinical efficacy as analgesics requires further investigation.
  • Liquorice represents a potential source for developing new pain therapies.