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The Association of Vitamin D and Neurodevelopmental Status Among 2 Years Old Infants

Feby Juwita1, Lani Gumilang2, Nelly Amalia Risan1

  • 1Department of Child Health, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.

Global Pediatric Health
|August 5, 2021
PubMed

Insights

Vitamin D deficiency is common in infants, but this study found no link between vitamin D levels and overall neurodevelopmental status at two years of age. Some early developmental domains showed associations with vitamin D levels at birth.

Area of Science:

  • Pediatrics
  • Nutrition Science
  • Developmental Neuroscience

Background:

  • Inconsistent findings exist regarding the association between vitamin D and neurodevelopment in early life.
  • The first 1000 days are critical for infant development, with vitamin D playing a potential role.

Purpose of the Study:

  • To investigate the correlation between vitamin D deficiency and neurodevelopmental status in two-year-old infants.
  • To analyze the relationship between vitamin D levels and various neurodevelopmental domains.

Main Methods:

  • A cross-sectional study involving 109 two-year-old infants in West Java, Indonesia.
  • Vitamin D levels were measured, and neurodevelopmental status was assessed using the Ages and Stages Questionnaire, Third Edition (ASQ-3).
  • Spearman's Rank correlation and multiple regression models were employed for statistical analysis.

Main Results:

  • Over half (50.4%) of the infants exhibited vitamin D deficiency (<50 nmol/L).
  • The overall neurodevelopmental status of the infants was appropriate for their age.
  • No significant association was found between vitamin D levels and neurodevelopmental status at two years of age.
  • A correlation was observed between specific developmental domains and vitamin D levels measured at birth.

Conclusions:

  • Vitamin D deficiency is prevalent in the studied infant population.
  • Vitamin D levels at two years of age do not appear to be significantly associated with overall neurodevelopmental status.
  • Early-life vitamin D levels may influence specific aspects of infant development, warranting further investigation.

Keywords:
first 1000 days of lifeinfantneurodevelopmental statusvitamin D

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