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Published on: August 9, 2012
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Rodent models of ketamine-induced cystitis.
Saki Sultana1, Geraint Berger1, Ashley Cox2
1Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Neurourology and Urodynamics
|August 5, 2021
Summary
Rodent models are crucial for studying ketamine-induced cystitis (KIC) and developing treatments. This review summarizes current models, highlighting variations in induction and assessment for better therapeutic translation.
Area of Science:
- Urology
- Pharmacology
- Toxicology
Background:
- Long-term ketamine use can cause ketamine-induced cystitis (KIC), a painful urinary system condition.
- Rodent models are essential for understanding KIC pathophysiology and developing effective therapies.
Purpose of the Study:
- To review and summarize existing rodent models of KIC.
- To focus on disease induction, experimental methodologies, and observed pathological features.
Main Methods:
- A literature search was conducted using the NCBI PubMed database up to March 2021.
- Twenty articles were selected based on predefined inclusion criteria.
Main Results:
- Significant variations exist in rodent models of KIC.
- These variations include animal strain, ketamine dosage, administration route, duration, and pathological assessment methods.
Conclusions:
- Current rodent models of KIC have limitations in fully recapitulating the human condition.
- Enhanced characterization of models, experimental parameters, and translational limitations are needed to improve research value.
