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Published on: September 15, 2023
Prognostic significance and function of MCM10 in human hepatocellular carcinoma
Yi-Ru Chen1, Yi-Ting Li2, Mei-Qian Wang1
1Department of Gastroenterology & Hepatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Insights
High MCM10 gene expression indicates poor prognosis in hepatocellular carcinoma (HCC). MCM10 serves as a reliable prognostic indicator for HCC patients, improving survival prediction accuracy.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Hepatocellular carcinoma (HCC) is a major global health concern.
- Identifying reliable prognostic markers is crucial for effective HCC management.
- The role of the conserved replication factor MCM10 in HCC remains underexplored.
Purpose of the Study:
- To investigate the prognostic significance of MCM10 expression in hepatocellular carcinoma.
- To evaluate MCM10 as a potential biomarker for HCC patient outcomes.
Main Methods:
- Analysis of MCM10 expression data from 364 HCC patients in The Cancer Genome Atlas (TCGA) database.
- In vitro experiments to validate the functional role of MCM10.
- Prognostic accuracy assessment using time-dependent ROC curve analysis and C-index comparison.
Main Results:
- Elevated MCM10 expression strongly correlates with unfavorable HCC patient outcomes.
- MCM10 serves as an independent prognosticator for HCC.
- The prognostic performance of MCM10 is comparable to the tumor node metastasis stage.
- Incorporating MCM10 into multivariate models significantly enhances prognostic accuracy.
- Genetic alterations in MCM10 are associated with poorer HCC outcomes.
Conclusions:
- MCM10 is a promising prognostic indicator for hepatocellular carcinoma.
- The study supports the clinical utility of MCM10 for predicting HCC patient survival.
Abstract:
Aim: To investigate the role of MCM10, a conserved replication factor, in hepatocellular carcinoma (HCC). Methods: We used data from 364 HCC patients in the Cancer Genome Atlas database and conducted in vitro experiments to confirm the role of MCM10. Results: High MCM10 expression correlated with poor HCC patient outcome and was an independent prognosticator for HCC. Time-dependent receiver operating characteristic curve analysis found that the sequential trend of MCM10 for survival was not inferior to that of the tumor node metastasis stage. The MCM10 model had a higher C-index than the non-MCM10 model, indicating that incorporating MCM10 into a multivariate model improves the model's prognostic accuracy for HCC. Genetic alterations of MCM10 prominently correlated with an unfavorable HCC outcome. Conclusion: Our findings strongly suggest using the MCM10 gene as a prognostic indicator in HCC.
