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Does Blood Pressure Variability Affect Hypertension Development in Prehypertensive Patients?
Gülsüm Özkan1, Şükrü Ulusoy2, Mustafa Arıcı3
1Department of Nephrology, Tekirdağ Namık Kemal University, School of Medicine, Tekirdağ, Turkey.
American Journal of Hypertension
|August 5, 2021
Summary
Short-term blood pressure variability (BPV) can predict hypertension development in prehypertensive individuals. Higher average real variability (ARV) in 24-hour ambulatory blood pressure monitoring (ABPM) and home measurements at baseline indicated increased risk.
Area of Science:
- Cardiology
- Hypertension Research
- Clinical Trials
Background:
- Blood pressure variability (BPV) is linked to organ damage and cardiovascular issues in hypertension.
- Prehypertension is a common precursor to developing full hypertension (HT).
- Understanding factors predicting HT development is crucial for early intervention.
Purpose of the Study:
- To assess how blood pressure variability (BPV) influences the onset of hypertension (HT).
- To determine if BPV measurements can predict future hypertension in prehypertensive patients.
Main Methods:
- A 2-year prospective observational cohort study of 207 prehypertensive patients.
- Regular 24-hour ambulatory blood pressure monitoring (ABPM), office BP, and home BP measurements.
- Calculation of average real variability (ARV) from BP data at baseline to assess BPV.
Main Results:
- Hypertension (HT) developed in 25.60% of the study participants.
- Significantly higher baseline 24-hour ABPM systolic (SBP) and diastolic (DBP) ARV, and home SBP ARV were observed in those who developed HT.
- Baseline 24-hour ABPM SBP ARV and home SBP ARV above the 90th percentile were identified as predictors of HT development.
Conclusions:
- Short-term blood pressure variability (BPV) is a significant predictor of hypertension development.
- Ambulatory and home blood pressure variability measurements can identify prehypertensive individuals at higher risk for HT.
- This finding supports the use of BPV monitoring for early risk stratification in prehypertension.
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