Andrographolide, a novel inducer of apelin gene expression

Area of Science:

• Pharmacology and Molecular Biology
• Metabolic Research

Background:

• Andrographis paniculata (A. paniculata) is a traditional herb with diverse medicinal properties.
• It exhibits antibacterial, antifungal, antiviral, anti-neoplasm, hepatoprotective, hypoglycemic, and hypocholesterolemic effects.

Purpose of the Study:

• To investigate the impact of Andrographolide on apelin gene expression.
• To assess the effect of Andrographolide on serum glucose levels.

Main Methods:

• Male Wistar rats were divided into control, 3.5 mg/kg, and 7 mg/kg Andrographolide groups.
• Apelin gene expression was quantified using real-time PCR.
• Serum glucose levels were measured photometrically.

Main Results:

• Andrographolide administration (3.5 and 7 mg/kg) significantly elevated hepatic apelin gene expression (p < 0.05).
• Serum glucose levels decreased in a dose-dependent manner with Andrographolide treatment.
• HDL-c levels decreased, and the LDL-c/HDL-c ratio increased.

Conclusions:

• Andrographolide enhances hepatic apelin gene expression.
• Andrographolide effectively reduces serum blood glucose levels.
• Further research into Andrographolide's metabolic effects is warranted.