Related Experiment Video
Updated: Oct 25, 2025
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Biomarcadores y endotipos en la sepsis. Nuevas evidencias
Ansony R Godínez-Vidal1, Raúl Carrillo-Esper2, Ricardo Cabello-Aguilera3
1Servicio de Cirugía General, Hospital HMG Coyoacán, Ciudad de México, México.
Antecedentes:
La sepsis es una causa importante de enfermedad y muerte en todo el mundo, y es un proceso complejo y heterogéneo. Ahora se reconoce que los marcadores biológicos mejoran la clasificación de la sepsis y pueden facilitar la identificación de distintas subclases o endotipos de pacientes.
Objetivo:
Analizar los conceptos actuales en biología traslacional que ayudan a entender la heterogeneidad en la respuesta del paciente con sepsis.
Conclusiones:
Hay una serie de biomarcadores que podrían ser útiles para construir endotipos compuestos que predicen resultados no complicados en la sepsis. Estos endotipos podrían ayudar a identificar a los pacientes que merecen el inicio temprano de antimicrobianos o la interrupción de estos.
Background:
Sepsis is an important cause of disease and death worldwide, and it has a complex and heterogeneous disease process. It is now recognized that biological markers improve sepsis classification and may facilitate the identification of different subclasses or endotypes of patients.
Objective:
To analyze the current concepts in translational biology that help to understand the heterogeneity in the response of the patient with sepsis.
Conclusions:
There are a number of biomarkers that could be useful for constructing endo-compound types that predict uncomplicated results in sepsis. These endotypes could help identify patients who deserve early antimicrobial onset or discontinuation.
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