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Updated: Oct 25, 2025
Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
Development of a small-molecule-based activatable photoacoustic probe.
Takayuki Ikeno1, Kenjiro Hanaoka1, Yasuteru Urano2
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Researchers developed a new activatable photoacoustic (PA) probe, PA-MMSiNQ, for visualizing hypochlorous acid (HOCl) activity. This probe enhances functional imaging by detecting changes in PA signals, aiding in molecular target visualization.
Area of Science:
- Biomedical Imaging
- Chemical Biology
- Molecular Imaging
Background:
- Photoacoustic (PA) imaging merges optical and ultrasound advantages for functional imaging.
- Activatable PA probes are crucial for visualizing molecular presence and activity via signal changes.
Purpose of the Study:
- To describe the development of small-molecule-based activatable PA probes.
- To focus on the design and synthesis of PA-MMSiNQ, a novel probe for HOCl detection.
Main Methods:
- Design and synthesis of small-molecule activatable PA probes.
- Evaluation of PA-MMSiNQ using UV-vis spectroscopy.
- Assessment of PA-MMSiNQ with a PA imaging microscope.
Main Results:
- Successful development of PA-MMSiNQ, an activatable PA probe.
- Demonstration of PA-MMSiNQ's capability to detect HOCl.
- Characterization of probe performance using spectroscopic and microscopic methods.
Conclusions:
- Small-molecule activatable PA probes offer advanced functional imaging capabilities.
- PA-MMSiNQ represents a significant development for HOCl detection.
- The described protocols facilitate the evaluation of novel PA probes.
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