Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Kernel-based maximum likelihood reconstruction of attenuation and activity (MLAA) in SPECT imaging for improved attenuation correction and activity quantification: simulation, phantom and patient validation studies.

Physics in medicine and biology·2026

Same author

Childhood Verbal Abuse: Expert-Informed Delphi Consensus on Definition and Actions.

Child maltreatment·2026

Same author

EXPRESS: Single-tracer [<sup>18</sup>F]FDG PET quantification of blood-brain barrier permeability and cerebral blood flow: Validation using dual-tracer PET.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026

Same author

Cyanobacterial extracellular polymeric substances empowered biological aqua crust formation via selective mineral adsorption for sustainable metal(loid) bioremediation.

Journal of hazardous materials·2026

Same author

Costs associated with anastomotic leak after left-sided colorectal surgery: retrospective real-world study in England.

BJS open·2026

Same author

Oxygenic photogranules in wastewater treatment: Formation mechanisms, engineering optimization and prospects.

Bioresource technology·2026

Search research articles

Related Experiment Video

Updated: Oct 25, 2025

A Step-by-Step Implementation of DeepBehavior, Deep Learning Toolbox for Automated Behavior Analysis

A Step-by-Step Implementation of DeepBehavior, Deep Learning Toolbox for Automated Behavior Analysis

Published on: February 6, 2020

Total-Body PET Kinetic Modeling and Potential Opportunities Using Deep Learning.

Yiran Wang¹, Elizabeth Li², Simon R Cherry¹

¹Department of Biomedical Engineering, University of California, 451 E. Health Sciences Drive, Davis, CA 95616, USA; Department of Radiology, University of California Davis Medical Center, Ambulatory Care Center, Building Suite 3100, 4860 Y Street, Sacramento, CA 95817, USA.

|August 6, 2021

Summary

Total-body positron emission tomography/computed tomography (PET/CT) enables dynamic imaging for precise tracer kinetic quantification. This technology presents challenges and opportunities for advanced kinetic modeling and parametric imaging.

Keywords:

Deep learning Dynamic imaging Kinetic modeling Parametric imaging Total-body PET

More Related Videos

Tracking Rats in Operant Conditioning Chambers Using a Versatile Homemade Video Camera and DeepLabCut

Tracking Rats in Operant Conditioning Chambers Using a Versatile Homemade Video Camera and DeepLabCut

Published on: June 15, 2020

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

Published on: July 10, 2019

Related Experiment Videos

Last Updated: Oct 25, 2025

A Step-by-Step Implementation of DeepBehavior, Deep Learning Toolbox for Automated Behavior Analysis

A Step-by-Step Implementation of DeepBehavior, Deep Learning Toolbox for Automated Behavior Analysis

Published on: February 6, 2020

Tracking Rats in Operant Conditioning Chambers Using a Versatile Homemade Video Camera and DeepLabCut

Tracking Rats in Operant Conditioning Chambers Using a Versatile Homemade Video Camera and DeepLabCut

Published on: June 15, 2020

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

Published on: July 10, 2019

Area of Science:

Medical Imaging
Nuclear Medicine
Pharmacokinetics

Background:

The uEXPLORER total-body PET/CT system offers unprecedented detection sensitivity and whole-body coverage.
Dynamic imaging is crucial for accurate quantification of tracer kinetics throughout the entire body.

Purpose of the Study:

To describe the principles and advantages of total-body kinetic modeling and parametric imaging.
To highlight methods for noninvasive blood input function derivation and multiparametric imaging with high temporal resolution.

Main Methods:

Utilizing the uEXPLORER total-body PET/CT system for dynamic imaging.
Developing and applying total-body kinetic modeling techniques.
Investigating noninvasive methods for blood input function estimation.

Main Results:

Total-body kinetic modeling allows for comprehensive analysis of tracer distribution and kinetics.
High-temporal resolution enables detailed study of dynamic processes.
Challenges include managing large datasets, selecting appropriate models, and motion correction.

Conclusions:

Total-body kinetic modeling offers significant potential for advancing quantitative imaging.
Deep learning presents promising solutions for overcoming current challenges in total-body PET data analysis.