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Age-related differences in isolated rat sinus node function.

M Di Gennaro1, R Bernabei, A Sgadari

  • 1Cattedra di Gerontologia, Università Cattolica del Sacro Cuore, Rome, Italy.

Basic Research in Cardiology
|November 1, 1987
PubMed
Summary
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Aging reduces sinus node rate (SNR) in isolated rat hearts, independent of neuromediator responses. This decline in intrinsic sinus node cell activity may explain age-related heart rate changes.

Area of Science:

  • Cardiovascular Physiology
  • Aging Research
  • Cardiac Electrophysiology

Background:

  • Sinus node (SN) function is critical for heart rate regulation.
  • Age-related changes in cardiovascular function are well-documented, but SN function requires further investigation.

Purpose of the Study:

  • To investigate age-related differences in isolated sinus node (SN) function.
  • To determine the impact of various substances on SN rate in adult versus old rats.

Main Methods:

  • Isolated SN preparations from adult (4-5 months) and old (24-25 months) rats were used.
  • The effects of acetylcholine, adenosine, isoproterenol, and varying calcium concentrations on SN rate were assessed.

Main Results:

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  • While in vivo heart rate showed no difference, isolated SN rate was significantly lower in old rats.
  • Responses to acetylcholine and isoproterenol were similar between age groups.
  • Adenosine response was significantly higher in adult rats.
  • High calcium increased SN rate more significantly in old rats.

    • Conclusions:

    • An age-related decrease in isolated SN rate occurs.
    • This decline is likely due to altered intrinsic SN cell activity, not differential responses to tested neuromediators.