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Potential protective effects of Aloe vera gel on cardiovascular diseases: A mini-review
Saeideh Sabbaghzadegan1,2, Haide Golsorkhi1,2, Mohammad Hossein Soltani3
1School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.
Insights
Aloe vera gel (AVG) shows potential in managing cardiovascular disease (CVD) risk factors, with pre-clinical and clinical studies indicating beneficial effects. Further research is needed to confirm its efficacy for heart health.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Herbal Medicine
Background:
- Cardiovascular diseases (CVDs) are leading causes of global morbidity and mortality.
- Risk factors include hyperlipidemia, diabetes, hypertension, obesity, smoking, and poor diet.
- Herbal medicines like Aloe vera gel (AVG) are being investigated as complementary CVD treatments.
Purpose of the Study:
- To review clinical, in vitro, and in vivo studies on the cardiac benefits of Aloe vera gel (AVG).
- To assess the potential of AVG in managing cardiovascular disease risk factors.
Main Methods:
- Systematic review of clinical trials.
- Review of in vitro and in vivo pre-clinical studies on AVG's biological activities.
- Analysis of AVG's effects on CVD risk markers.
Main Results:
- Pre-clinical studies indicate AVG possesses antidiabetic, lipid-lowering, antioxidant, anti-inflammatory, and hepatoprotective effects.
- AVG also exhibits anti-fibrotic, anti-hypertensive, and anti-atherosclerotic properties.
- Clinical studies suggest AVG can ameliorate certain CVD risk factors.
Conclusions:
- Aloe vera gel (AVG) demonstrates promising effects on cardiovascular health and risk factors.
- Further high-quality clinical studies are required to establish the definitive efficacy of AVG for CVD management.
Abstract:
Cardiovascular diseases (CVDs) comprise the most prevalent causes of morbidity and mortality in both men and women worldwide. CVDs are associated with several risk factors such as hyperlipidemia, diabetes mellitus, hypertension, obesity, tobacco smoking and an unhealthy diet. Currently, in addition to the use of related pharmacological treatments in the management of CVDs, the investigation of other suitable healthcare approaches for these disorders such as the identification of herbal medicines has been considered in the scientific communities. Aloe vera (L.) Burm.f. is a perennial medicinal plant. The innermost leaf layer of this plant contains transparent gel, which is used as food. Pre-clinical studies have shown several biological activities of A. vera gel (AVG), including antidiabetic, lipid-lowering, antioxidant, antiinflammatory, hepatoprotective, and immunomodulatory effects. Other pharmacological activities of AVG such as anti-fibrotic, anti-hypertensive, and anti-atherosclerotic effects have been reported. Moreover, several clinical studies have demonstrated the ameliorating effects of AVG on some markers of CVDs risk factors. Thus, this study was conducted to review clinical trials besides in vitro and in vivo studies on the cardiac beneficial effects of AVG. However, further high-quality studies are needed to firmly establish the clinical efficacy of the plant.
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