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Vitamin D and Blood Parameters.

Thomas Müller1, Lutz Lohse2, Andreas Blodau3

  • 1Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088 Berlin, Germany.

Biomolecules
|August 6, 2021
PubMed
Summary
This summary is machine-generated.

Vitamin D levels impact red blood cell parameters. Higher vitamin D concentrations correlate with improved mean corpuscular hemoglobin and volume, suggesting better oxygen transport.

Keywords:
bloodhaematocritvitamin D

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Area of Science:

  • Endocrinology
  • Hematology
  • Nutritional Science

Background:

  • Vitamin D, a steroid hormone, is vital for numerous physiological processes post-hydroxylation.
  • Its chemical structure resembles anabolic steroids.

Purpose of the Study:

  • To examine the relationship between 25-hydroxy-vitamin D plasma levels and key blood parameters.
  • Specifically investigating erythrocytes, hematocrit, mean corpuscular hemoglobin (MCH), and mean corpuscular volume (MCV).

Main Methods:

  • Serial blood assessments were conducted on 290 patients with multiple sclerosis over approximately 245 days.
  • Vitamin D supplementation was recommended for individuals with levels below 20 ng/mL.

Main Results:

  • Changes in vitamin D levels (fall or rise) were observed in most participants.
  • Declining vitamin D was associated with lower MCH and MCV increases compared to vitamin D elevation.
  • Inverse correlations were noted between vitamin D changes and erythrocyte counts or hematocrit.

Conclusions:

  • Elevated vitamin D plasma levels appear to create favorable conditions for enhanced cellular oxygenation.
  • This suggests a potential role for vitamin D in optimizing tissue oxygen delivery.