Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ultrasound image abnormalities associated with the development of ovine pulmonary adenocarcinoma.

Research in veterinary science·2025

Same author

Corrigendum: Comparative analysis of the development of acquired radioresistance in canine and human mammary cancer cell lines.

Frontiers in veterinary science·2025

Same author

Spatial encoding and growth-related change of sheep lung radiomic features.

Frontiers in veterinary science·2025

Same author

Solar geoengineering research faces geopolitical deadlock.

Science (New York, N.Y.)·2025

Same author

Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model.

Genes·2024

Same author

Special Issue "Cancer Biomarker Research and Personalized Medicine 2.0".

Journal of personalized medicine·2024

Search research articles

Related Experiment Video

Updated: Oct 25, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Tissue- and Liquid-Based Biomarkers in Prostate Cancer Precision Medicine.

James Meehan¹, Mark Gray², Carlos Martínez-Pérez^1,3

¹Translational Oncology Research Group, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.

Journal of Personalized Medicine

|August 6, 2021

Summary

Prostate cancer (PC) management needs better biomarkers beyond prostate-specific antigen (PSA) for diagnosing aggressiveness and predicting treatment response. Novel biomarkers are crucial for precision medicine in PC.

Keywords:

liquid-based biomarkers precision medicine prostate cancer tissue-based biomarkers

More Related Videos

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

Related Experiment Videos

Last Updated: Oct 25, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

Area of Science:

Oncology
Biomarker Discovery
Precision Medicine

Background:

Prostate cancer (PC) is a leading cause of cancer death in men.
Current PC diagnosis relies on clinical signs and prostate-specific antigen (PSA) levels, which lack specificity and lead to over-diagnosis.
PC heterogeneity makes it difficult to distinguish aggressive from indolent tumors.

Purpose of the Study:

To review the progress in PC-specific biomarker research.
To highlight the unmet need for prognostic and predictive biomarkers for PC management.
To discuss novel biomarkers that can predict aggressiveness and treatment response.

Main Methods:

Review of current literature on PC biomarker research.
Analysis of evolving PSA-based tests and newly approved assays.
Exploration of genomic and proteomic techniques for biomarker identification.

Main Results:

Advances in genomic and proteomic techniques are identifying novel tissue, blood, and urine-based PC biomarkers.
Research is progressing on alternative diagnostic biomarkers to PSA.
Biomarkers for predicting PC aggressiveness and treatment response are under development.

Conclusions:

Novel biomarkers hold significant potential to improve PC clinical management.
There is a critical need for biomarkers that indicate disease aggressiveness at diagnosis.
Future research aims to supplement or replace current practices with more precise diagnostic and prognostic tools.