[Raman spectroscopy and its application in different areas of medicine]

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Medical Diagnostics

Background:

• Raman spectroscopy is a versatile technique with broad applications in various scientific fields.
• Its advantages include minimal sample preparation, low sample volume requirements, and contactless analysis of molecular information.
• High equipment costs are offset by the absence of recurring reagent expenses.

Purpose of the Study:

• To review the applications of Raman spectroscopy in medicine, with a specific focus on dentistry.
• To highlight the diagnostic capabilities of Raman spectroscopy in various medical and dental contexts.

Main Methods:

• The review synthesizes information on Raman spectroscopy's utility across different industries.
• Specific mention of combinatorial scattering for dermatological diagnostics (benign and malignant neoplasms).
• Focus on Raman spectroscopy's application in analyzing hard dental tissues and oral mucosa.

Main Results:

• Raman spectroscopy enables high-accuracy, automated visualization and diagnostics in dermatology.
• It serves as an analytical tool for disease diagnosis in both hard and liquid media without special sample treatment.
• In dentistry, it facilitates diagnosis and comparative analysis of hard tissue and oral mucosal changes.

Conclusions:

• Raman spectroscopy is a valuable diagnostic tool in medicine and dentistry.
• Its application in dentistry improves treatment safety, rationalization, and complication prevention.
• The technique offers unique insights into molecular conformation and microenvironments of cells.