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An Unusual Presentation of Blastomycosis-Like Pyoderma Gangrenosum

Richard Simman1, Darren Gordon2, Mary Steven3

  • 1Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio; Jobst Vascular Institute, ProMedica Health Network, Toledo, Ohio; University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio.

Wounds : a Compendium of Clinical Research and Practice
|August 6, 2021
PubMed
Abstract

Insights

Pyoderma gangrenosum (PG) is a rare inflammatory skin disease that can mimic other conditions. This case highlights the importance of considering diverse diagnoses for complex wounds to ensure appropriate treatment and prevent recurrence.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative skin disease with diverse clinical presentations.
  • Accurate diagnosis is crucial as misdiagnosis can lead to treatment failure and wound recurrence.

Observation:

  • A 74-year-old female presented with a lesion initially suspected as squamous cell carcinoma.
  • The lesion's unusual presentation mimicked blastomycosis, complicating the initial diagnosis.

Findings:

  • Histopathological examination confirmed blastomycosis-like pyoderma gangrenosum.
  • Treatment with high-dose prednisone and skin grafts led to wound resolution.

Implications:

  • This case underscores the necessity of a broad differential diagnosis for complex wounds.
  • Multidisciplinary healthcare collaboration is vital for managing challenging cases of pyoderma gangrenosum.

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