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Updated: Oct 25, 2025

Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells
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Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells

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Molecular basis for substrate recruitment to the PRMT5 methylosome

Kathleen M Mulvaney1, Christa Blomquist1, Nischal Acharya1

  • 1Broad Institute, Cambridge, MA, USA.

Molecular Cell
|August 6, 2021
PubMed
Summary

Protein arginine methyltransferase 5 (PRMT5) uses a common binding motif on adaptor proteins to recruit substrates. Disrupting this interaction halts cancer cell growth, offering a therapeutic target for MTAP-null cancers.

Keywords:
CDKN2ACOPR5MTAPPRMT5RIOK1Sm proteinarginine methylationhistonepIClnsplicing

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