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Related Concept Videos

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Related Experiment Video

Updated: Oct 25, 2025

Models of Bone Metastasis
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Exercise for individuals with bone metastases: A systematic review.

Sarah Weller1, Nicolas H Hart2, Kate A Bolam3

  • 1Provincial Programs, BC Cancer, 750 West Broadway, Vancouver, BC, V5Z 1H5, Canada.

Critical Reviews in Oncology/Hematology
|August 6, 2021
PubMed
Summary

Supervised exercise is safe and feasible for individuals with bone metastases, showing potential benefits for physical function and quality of life. This systematic review highlights the importance of qualified professionals in exercise interventions for this population.

Keywords:
bone neoplasmsexerciseneoplasm metastasisneoplasmsrehabilitationsportssystematic review

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Area of Science:

  • Oncology
  • Exercise Science
  • Rehabilitation Medicine

Background:

  • Bone metastases often lead to exercise avoidance due to safety concerns.
  • Exercise interventions can potentially improve physical function and quality of life in patients with bone metastases.
  • This systematic review evaluates the safety, feasibility, and efficacy of exercise in controlled trials for individuals with bone metastases.

Purpose of the Study:

  • To systematically review the safety, feasibility, and efficacy of exercise interventions in controlled trials involving individuals with bone metastases.
  • To assess adverse events associated with exercise in this population.
  • To synthesize findings on the impact of exercise on physical function and quality of life.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (MEDLINE, Embase, Pubmed, CINAHL, PEDro, CENTRAL) up to July 16, 2020.
  • Included studies were controlled trials investigating exercise interventions (aerobic, resistance, soccer) in individuals with bone metastases.
  • Data on safety, feasibility, and efficacy outcomes were extracted and synthesized.

Main Results:

  • Seventeen trials were included, utilizing aerobic, resistance, or soccer-based exercise programs.
  • A low incidence of serious adverse events (0.5%) was reported, with no events directly linked to bone metastases.
  • Efficacy results were mixed, indicating exercise may lead to positive changes or no significant change in outcomes.
  • The majority of trials (94%) featured supervised exercise instruction delivered by qualified professionals (76%).

Conclusions:

  • Exercise interventions appear to be safe and feasible for individuals diagnosed with bone metastases.
  • Supervised exercise instruction, delivered by qualified professionals, is a key component for safe and effective exercise participation.
  • Further research may clarify optimal exercise protocols to maximize benefits for this patient group.